A Hyaluronic Acid Hydrogel Loaded with Gentamicin and Vancomycin Successfully Eradicates Chronic Methicillin-Resistant Staphylococcus aureus Orthopedic Infection in a Sheep Model
نویسندگان
چکیده
Implantable orthopedic devices have had an enormously positive impact on human health; however, despite best practice, patients are prone to developing device-related infections (ODRI) that high treatment failure rates. One barrier the development of improved options is lack animal model may serve as a robust preclinical assessment efficacy.
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2021
ISSN: ['0066-4804', '1070-6283', '1098-6596']
DOI: https://doi.org/10.1128/aac.01840-20